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KMID : 0390019930030020045
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Pediatric Allergy and Respiratory Disease
1993 Volume.3 No. 2 p.45 ~ p.53
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A Study of the Subtypes of Peripheral T Cell in Wheezy Infants and Toddlers
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Abstract
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There is some evidence in bronchial asthma that the number and the function of T4(+) cells and of T8(+) cells decrease but that T(8) cells decrease less than T4(+) cells. These decreases represent one of the pathogenesis of excessive production
of
IgE
and of bronchial asthma.
We studied whether or not the subtypes of T cells also change in wheezing infants and toddlers.
@ES The results were as follows :
@EN 1. Compared to those of control patients, the percentages of T4(+) cell and T8(+) cell were high and the ratio of T4/T8 was low in wheezy patients but there was significance in the percentage of T8(+) cell(21.3% versus 31.0%, p<0.05).
2. Compared to those of acute period the percentages of T4(+) cell and T8(+) cell and the ratio of T4/T8 were significantly decreased in convalescent period.
3. There was a significant correlation between percentage of T8(+) cell and the levels of IgE in wheezy patients.
4. There was a significant negative correlation between the T4(+) cell(%) and age(month) in wheezy patients.
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KEYWORD
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